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A.G. Scientific, Inc
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  •   Dithiothreitol or DTT is also known as Cleland’s Reagent. It contains two thiol groups and is commonly used to reduce disulfide bond in proteins. It can protect many thiol-containing biomolecules such as coenzyme A (Co-A), GSH (glutathione) from forming disulfide bonds. Not only does DTT scavenge the hydroxyl radical that attacks DNA and proteins, … Continue reading Dithiothreitol aka Cleland’s ...

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A.G. Scientific, Inc
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Neomycin Applications

  • Neomycins are a family of broad-spectrum highly toxic antibiotics produced by Streptomyces fradiae. Neomycin usually exists as a complex composed of two stereoisomers, neomycin B and neomycin C, which are the two active components. A third component, neomycin A, which is a degradation product, is present in small quantities. Neomycin C was isolated by DUTCHER et al. Neomycin C is … Continue readin...

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A.G. Scientific, Inc
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  • Ammonia (NH3) is a poisonous and pungent-smelling colorless gas that makes the eyes water. Ammonia is readily soluble in water. The aqueous solution has an alkaline reaction and is known as ammonia water or tincture of ammonia. In conjunction with acid, ammonia forms salts that disassociate in water, to form ammonium ions (NH4 +) and … Continue reading Nonactin based biosensors to measure ammonia ...

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A.G. Scientific, Inc
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  • Beta-lactam antibiotics are used to treat a broad spectrum of Gram-positive and Gram-negative bacteria.  Beta-lactam antibiotics target the penicillin-binding proteins or PBPs – a group of enzymes found attached in the cell membrane, which are involved in the cross-linking of the bacterial cell wall. The beta-lactam ring portion of this group of antibiotics binds to these different PBPs, rendering...

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A.G. Scientific, Inc
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  • Pinacidil Monohydrate is a guanidine that opens potassium channels producing direct peripheral vasodilatation of arterioles. It has been used as a vasodilator drug to treat hypertension. Apart from the above-mentioned application Pinacidil Monohydrate has also been gaining recognition in the field of stem cell research. Pinacidil has been successfully used in enhancing survival of stem … Continue ...

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A.G. Scientific, Inc
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  • Carnosic acid is a plastidial catecholic diterpene found in herb extracts such as Rosemary, Sage and Oregano. Carnosic acid has anti oxidant and anti microbial properties. Carnosic acid is increasingly exploited within food, nutritional health and Veterinary Medicine. Medicine: Novel Neuroprotective Compound Carnosic Acid has potent antioxidant and potent neuroprotective activity. It has been sugg...

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A.G. Scientific, Inc
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  • Forskolin is an extract from the root of Coleus Forskohlii.  C. Forskholii, a member of the mint family, is a perennial herb with fleshy and fibrous roots. It is commonly found in India, Burma and Thailand. The medicinal value of C. Forskohlii was first researched in early to mid-1980’s.   Forskolin activates adenylate cyclase by direct … Continue reading Forskolin- A natural weight loss remedy! T...

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A.G. Scientific, Inc
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  • Bafilomycin A1 is a macrolide antibiotic isolated from Streptomyces species. Baf-A1 is an autophagy inhibitor, cell growth inhibitor and apoptosis inducer. Up until 2016 there have been several papers and studies that provide evidence that Baf-A1 is an autophagy inhibitor that prevents cancer cell proliferation and tumor regrowth in different cancer cell lines such as … Continue reading Bafilomyci...

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A.G. Scientific, Inc
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  • Bafilomycin A1 is a macrolide antibiotic isolated from Streptomyces species. Baf-A1 is an autophagy inhibitor, cell growth inhibitor and apoptosis inducer. Up until 2016 there have been several papers and studies that provide evidence that Baf-A1 is an autophagy inhibitor that prevents cancer cell proliferation and tumor regrowth in different cancer cell lines such as […] The post Bafilomycin A1 a...

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A.G. Scientific, Inc
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  • Any scientist involved in proteomics or protein engineering, will stand by the fact that detergents are indispensable tools for isolation and solubilization of integral membrane proteins, and protein complexes from biological membranes. It is very important to have intact protein structures in their native biological form in order to study their structure, function, dynamics and … Continue reading...

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A.G. Scientific, Inc
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ETYA

  • Neurological disorders are diseases that affect the brain, central and the autonomic nervous system. According to the University Of California San Francisco, there are more than 600 neurological disorders. Of the many neurological disorders, the most common neurodegenerative diseases among US population is Alzheimer’s and Multiple sclerosis. The Multiple Sclerosis Foundation estimates that more th...

A.G. Scientific, Inc
A.G. Scientific, Inc
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  • Proteins control almost every function of the cell. Any mutation in the structure of the protein or inhibition of its function; in short any issue that can hamper the function will lead to abnormal functioning of the cells and in turn cause diseases. Therefore it is very important to meticulously learn and get a better understanding … Continue reading Detergents – Important tools for membrane prot...

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A.G. Scientific, Inc
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  • 1.What are Bio Detergents? Detergents are soluble amphiphilic molecules that are able to incorporate to liposomes and cell membranes. They are essential tools for the study of biological membranes, as they are frequently used to solubilize membrane proteins and to investigate the interactions among membrane lipid components.   2.  What are the different types of … Continue reading 18 Fast Facts ab...

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A.G. Scientific, Inc
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  • To lead a healthy lifestyle it is essential to eat healthy and exercise regularly. People who exercise regularly would often reach a point during their workout session, where they feel extremely exhausted and could not carry on any further. Fatigue sets in when lactate (a form of Lactic acid) builds up in the muscles. Lactic … Continue reading Lactate Levels at your tattoo tips! The post Lactate L...

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A.G. Scientific, Inc
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  • Lactic acid is an end product of Glycolysis under anaerobic conditions. There are 2 optically active stereoisomers of lactic acid: L-Lactic acid – produced by muscles during anaerobic glycolysis and by most of the lactic acid bacteria. D-Lactic acid – Produced by some bacteria, plants and algae. Lactate and lactic acid detection is very important … Continue reading Lactate Oxidase in Food Industry...

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A.G. Scientific, Inc
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  • Lactate detection and quantification plays a vital role in healthcare, especially in conditions such as hemorrhage, sepsis, tissue hypoxia, respiratory failure and kidney failure. It also has a key role in sports medicine where it is essential in monitoring athletes. Lactate Oxidase is an enzyme which is predominantly used in the detection of Lactate. This … Continue reading 12 facts about Lactate...

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A.G. Scientific, Inc
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  • Discovery of Rapamycin Rapamycin is a macrocyclic triene antibiotic that binds to the cytosolic protein FK-binding protein 12 (FKBP12) and inhibits mTOR pathway by directly binding to the mTOR Complex1 (mTORC1). It is a potent immunosuppressant having  a variety of uses both in vitro and in vivo and is used to prevent organ rejection after … Continue reading 18 Facts about Rapamycin The post 18 Fa...

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A.G. Scientific, Inc
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  •   The common causes of acute diarrhea are viruses and bacteria. Diarrhea is a symptom of infections caused by a host of bacterial, viral and parasitic organisms, most of which are spread by feces-contaminated water. Escherichia coli (E. coli) are a large and diverse group of bacteria. Although most strains of E. coli are harmless, … Continue reading How Safe Is Your Water? The post How Safe Is You...

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A.G. Scientific, Inc
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  • The sodium salt form of cefsulodin, a semi-synthetic, third-generation cephalosporin antibiotic has a narrow spectrum of activity. Cefsulodin has specific activity against Pseudomonas aeruginosa and Staphylococcus aureus but little or no activity against other gram negative and gram positive bacteria.    1.What is cefsulodin sodium? Cefsulodin Sodium is a semi-synthetic third generation cephalospo...

A.G. Scientific, Inc
A.G. Scientific, Inc
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  • Here are a few facts about RNase A: Introduction Ribonucleases (RNases) are a large group of hydrolytic enzymes that degrade Ribonucleic Acid (RNA) molecules. RNases are nucleases that catalyze the breakdown of RNA into smaller components. RNases are a superfamily of enzymes which catalyzing the degradation of RNA operate at the levels of transcription and … Continue reading 17 need to know facts ...

A.G. Scientific, Inc
A.G. Scientific, Inc
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  • Stem cell therapies are the leading and most sensational topic in the world of scientific research. The excitement is due to the huge potential these cells have in curing human diseases. What are stem cells? They are undifferentiated cells in human body that are capable of differentiating into specialized cell types. Stem cells differentiate into … Continue reading CHIR 99021 GSK3 Inhibitor’s Role...

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A.G. Scientific, Inc
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  • Gentamycin G-1067 What is Gentamycin Sulfate? Gentamycin Sulfate, is also known as Gentamycin, is one of many broad-spectrum, cell culture antibiotic that is non toxic to viruses and mammalian cells at an antibacterial levels. Also, it is used to treat several types of bacterial infections such as bone infections, endocarditis, pelvic inflammatory disease, meningitis, pneumonia, urinary … Continue...

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A.G. Scientific, Inc
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New blog articles detected.

  • Top 7 Carbenicillin Antibiotic FAQs

    Using Carbenicillin antibiotics in your research? Get to know these top frequently asked questions! What is Carbenicillin? Carbenicillin, also known as carboxybenzylpenicillin, is a member of the penicillin β-lactam antibiotics. Unlike most β-lactams, carbenicillin disodium is limited to primarily gram-negative bacteria including Pseudomonas aeruginosa and common enteric species. It can be used in...

  • 19 Need To Know Facts About PMSF Inhibitors

    Here are the 19 Need to know facts about PMSF inhibitors: PMSF or Phenylmethylsulfonyl fluoride is a serine protease inhibitor. It targets serine proteases, including trypsin, chymotrypsin, thrombin and thiol proteases such as papain. Typically its effect is irreversible with the exception of DTT treatment. PMSF is commonly used in protein solubilization in order to deactivate proteins … Continue ...

  • Screens, Genes & The Choices We Make

    Joan Lunden, former co-host of “Good Morning America”, author and breast cancer survivor to moderate Susan G. Komen San Diego’s “Screens, Genes & The Choices We Make” Leading cancer experts share the latest breast cancer research, treatments, new scientific findings and the role of mindfulness as it relates to health and well-being; innovative breast cancer screening breakthrough to be presented S...

  • Top 10 FAQs About Inhibitor CHIR99021

    Any questions about Inhibitor CHIR99021? See all about it in the post below. What is inhibitor CHIR99021? CHIR99021 (CT99021), is also known as 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile and CT99021. It is the most potent and selective inhibitor of GSK3. CHIR99021 is an aminopyrimidine derivative. It inhibits GSK3 β and GSK3...

  • AG Scientific Spotlight: Sam Hashemian

    Meet Sam, our senior inbound marketing and social media coordinator at AG Scientific. He is a student at SDSU studying marketing. He shares a bit about himself in the post below.   Q1. Could you introduce yourself?  My name is Sam. I was born in Toronto, Canada, and I moved to San Diego I was 4 … Continue reading AG Scientific Spotlight: Sam Hashemian The post AG Scientific Spotlight: Sam Hashemia...

  • The CHIR99021 GSK-3 Inhibitor Mechanism

    The CHIR99021 GSK-3 Inhibitor is both potent and selective. Small membrane-permeable molecules are widely utilized for maintenance and differentiation of embryonic stem cells (ES) of different species. Glycogen synthase kinase 3 (GSK3) activates the Wnt/beta-catenin pathway when targeted for inhibition. GSK3 is a conserved signaling molecule with essential roles in diverse biological processes. GS...

  • AG Scientific Spotlight: Shannon Park

    Before coming to AG Scientific, Inc., our intern Shannon spent a few months living in Washington DC. She shares a bit about herself in the post below. Q1. Could you introduce yourself? My name is Seungah, but you can call me Shannon. I am a participant of a Korea government program which is made for … Continue reading AG Scientific Spotlight: Shannon Park The post AG Scientific Spotlight: Shannon ...

  • Thapsigargin Applications: Glioblastoma Multiforme Studies

    Glioblastoma multiforme is the most aggressive and malignant form of gliomas, a group of tumors arising from glial cells of the brain. Glioblastomas are very difficult to treat due to the diffused nature of the tumor itself. The tumor cells have a distinct invasive feature of spreading and diffusing into different parts of the brain. … Continue reading Thapsigargin Applications: Glioblastoma Multi...

  • A Promising Cancer Therapy: Thapsigargin’s Anti-Cancer Roles

    Thapsia Garganica is a common Mediterranean weed, but highly toxic to sheep and cattle, thus earning the nickname “death carrot”. Thapsigargin is a natural cytotoxin derived from the plant Thapsia Graganica. Oncologists Samuel Denmeade at Johns Hopkins University, Baltimore and his team has extensively researched methods to harness thapsigargin’s toxicity, and develop, as result, a novel … Continu...

  • What is Thapsigargin: Thapsigargin FAQ

    Thapsigargin is a naturally occurring tumor promoter derived from the plant Thapsia garganica. This effect is a result of emptying the intracellular calcium stores, which leads to a chain of events that causes apoptosis. What is thapsigargin? Thapsigargin is a naturally occurring sesquiterpene lactone. Abundant research and literature have proved thapsigargin to be tumorigenic, capable of … Contin...

A.G. Scientific, Inc
A.G. Scientific, Inc
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  • 2016 is a big year for cancer research! Research from across the world has been reporting a mix of good and bad, with the scariest showing a list of alcohol-related cancer diseases and the best news of all showing a trick to cheat death. Do you drink alcohol? Did you know that alcohol can cause … Continue reading Alcohol, Cancer, and Dying: Research 2016 The post Alcohol, Cancer, and Dying: Resear...

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A.G. Scientific, Inc
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