Cell Signaling Technology, Inc. (CST) is a privately held company that develops and produces antibodies, ELISA kits, ChIP kits, proteomic kits, and other related regents used to study the cell signaling pathways that impact human health. CST maintains an in-house research program, particularly in the area of cancer research, and has published scientific papers in many peer-reviewed journals.

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Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • It's almost time for the 2017 Society for Neuroscience meeting. To get your neurons excited for the meeting, here's a journal club discussing a recent paper with interesting findings for Alzheimer's disease.  The pathological hallmark of Alzheimer’s disease (AD) is the accumulation of amyloid β (Aβ) plaques and neurofibrillary tangles. Despite decades of research, the direct (and indi...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • You’re gathering data from all your experiments and preparing to present to your advisor and thesis committee at your annual progress report. You have an interesting hypothesis, and you have a validated antibody that recognizes your target protein on a western blot (WB). The molecular weight of the band is correct, and the expression of the target protein changes just the way you predi...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • Cell Signaling Technology is proud to partner with the Koch Institute at MIT, Science, and Science Signaling to present the Targeting Cancer Pathways webinar series. These webinars bring together thought leaders from around the world to share current findings and further cancer research community collaboration.

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • As a company that believes in leaving our mark on science, but not on the earth, CST has made a commitment to use compostable cups and plates in our US cafeterias.

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • This two part webinar features Dr. Li Huei Tsai from the Picower Institute at MIT and Dr. Raphael Rozenfeld who is a development scientist here at CST. Dr. Tsai discusses how modeling systems can be combined with immunolabeling and imaging techniques to unlock the mystery of Alzheimer's Disease. Dr Rozenfeld describes the rigorous validation procedure our antibodies undergo before be...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  •   If the thought of self-cannibalization is not appealing to you, you may not want to read the next sentence . . . Your cells are literally eating themselves right now! In the 1960s, Christian de Duve named this process “autophagy” from the Greek auto (self) and phagein (to eat). He was later awarded the Nobel Prize for Physiology or Medicine for his contribution to the cell biology f...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • Journal Club: YAP-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer. In the spirit of keeping you abreast of new and interesting scientific discoveries, the writers at CST have embraced the idea of a virtual journal club, where we discuss recently published scientific literature.

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • A picture is worth a thousand words, or in the case of immunofluorescent imaging, a thousand proteins. The images used to illustrate a scientific experiment should convey as much information as the text itself. Here at CST, we pride ourselves in the quality of our antibodies and our rigorous validation process. When we approve our primary antibodies for IF, we like to showcase them usi...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  •   If you’ve ever transitioned your IHC experiments from a manual protocol to an automated platform, you may have found the conversion process to be a drag. It isn’t an easy thing to do. For that reason, we’re happy to announce our IHC Leadership in Automation initiative. This rigorous validation initiative expands on our already thorough measures, allowing researchers to not only us...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • The development and testing of new products at Cell Signaling Technology (CST) involves the work of many teams using different techniques and technologies. This presents a variety of opportunities for summer interns to gain first-hand experience on projects ranging from bioinformatics to cell culture and staining tissue samples. For most students, a CST internship offers their first ex...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • Once a year, we slow the centrifuges, quit the cloning, and lose the lab coats, all in honor of relaxation. Our company party gives us a chance to talk about everything outside the lab. We grab a glass of wine or beer and salute the delicious lobsters that fought so bravely. We kick soccer balls and toss Frisbees. We compare notes on sand castle construction.

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • Cell Signaling Technology is proud to present the following On-Demand Webinar:  The Use of Highly Validated Antibodies and Optimized ChIP Assays to Analyze Epigenetic Marks and Mechanism in DIsease Sayura Aoyagi, Ph.D, CST Antibody Validation Scientist

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • Early exploration of unmapped biological signaling pathways were carried out using radiolabeled phospho-imaging. The development of phospho-specific antibodies to detect and quantify protein phosphorylation made life easier for researchers (less 32P waste to deal with), but the interpretation of data from these experiments comes with its own set of caveats. 

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • INTRODUCTION: We encourage you to explore the rich history of antibodies and to share our passion for research supporting the next wave of innovations in this field. Download or Request our 125 Years of Antibody Discovery and Development to learn great facts like: The Antigen-Antibody binding hypothesis was proposed in 1938 Hybritech was first company to produce antibodies comm...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • Lack of reproducibility in scientific studies has been a major topic of conversation lately. It's an important conversation for us to have, given the potential of this problem to affect how the research community views the published literature.  Many potential reasons for the problem exist, but CST is focused on the role vendors play in ensuring the reagents being used by the scientifi...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
YouTube Video
  • This webinar demonstrates how multiplex immunohistochemistry (mIHC) can be used to simultaneously investigate the expression pattern of multiple proteins, involved in immune checkpoint control, within the context of preserved tissue architecture. Key highlights: mIHC allows the simultaneous detection of multiple (more than 6) targets of interest in a species/isotype independent manner while provi...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
YouTube Video

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