Cell Signaling Technology, Inc. (CST) is a privately held company that develops and produces antibodies, ELISA kits, ChIP kits, proteomic kits, and other related regents used to study the cell signaling pathways that impact human health. CST maintains an in-house research program, particularly in the area of cancer research, and has published scientific papers in many peer-reviewed journals.

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Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
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  • 5 Steps to Publication-Worthy IF Images
    A picture is worth a thousand words, or in the case of immunofluorescent imaging, a thousand proteins. The images used to illustrate a scientific experiment should convey as much information as the text itself. Here at CST, we pride ourselves in the quality of our antibodies and our rigorous validation process. When we approve our primary antibodies for IF, we like to showcase them usi...
Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
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  • Switching from Manual to Automated IHC? We've got your back
      If you’ve ever transitioned your IHC experiments from a manual protocol to an automated platform, you may have found the conversion process to be a drag. It isn’t an easy thing to do. For that reason, we’re happy to announce our IHC Leadership in Automation initiative. This rigorous validation initiative expands on our already thorough measures, allowing researchers to not only us...
Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
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  • CST Interns: A Fun and Productive Summer for Future STEM Leaders
    The development and testing of new products at Cell Signaling Technology (CST) involves the work of many teams using different techniques and technologies. This presents a variety of opportunities for summer interns to gain first-hand experience on projects ranging from bioinformatics to cell culture and staining tissue samples. For most students, a CST internship offers their first ex...
Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
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  • Once a year, we slow the centrifuges, quit the cloning, and lose the lab coats, all in honor of relaxation. Our company party gives us a chance to talk about everything outside the lab. We grab a glass of wine or beer and salute the delicious lobsters that fought so bravely. We kick soccer balls and toss Frisbees. We compare notes on sand castle construction.
Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
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  • Discovery Through Validation: ChIP Assays
    Cell Signaling Technology is proud to present the following On-Demand Webinar:  The Use of Highly Validated Antibodies and Optimized ChIP Assays to Analyze Epigenetic Marks and Mechanism in DIsease Sayura Aoyagi, Ph.D, CST Antibody Validation Scientist
Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
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  • Have You Ever Wondered: What's The Lowdown on Phospho-Specific Antibodies?
    Early exploration of unmapped biological signaling pathways were carried out using radiolabeled phospho-imaging. The development of phospho-specific antibodies to detect and quantify protein phosphorylation made life easier for researchers (less 32P waste to deal with), but the interpretation of data from these experiments comes with its own set of caveats. 
Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
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  • 125 years of antibody history
    INTRODUCTION: We encourage you to explore the rich history of antibodies and to share our passion for research supporting the next wave of innovations in this field. Download or Request our 125 Years of Antibody Discovery and Development to learn great facts like: The Antigen-Antibody binding hypothesis was proposed in 1938 Hybritech was first company to produce antibodies comm...
Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
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  • Reproducibility in Research Science - Join the Discussion.
    Lack of reproducibility in scientific studies has been a major topic of conversation lately. It's an important conversation for us to have, given the potential of this problem to affect how the research community views the published literature.  Many potential reasons for the problem exist, but CST is focused on the role vendors play in ensuring the reagents being used by the scientifi...
Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
YouTube Video
Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
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  • Webinar Multiplex Immunohistochemistry IHC
    This webinar demonstrates how multiplex immunohistochemistry (mIHC) can be used to simultaneously investigate the expression pattern of multiple proteins, involved in immune checkpoint control, within the context of preserved tissue architecture. Key highlights: mIHC allows the simultaneous detection of multiple (more than 6) targets of interest in a species/isotype independent manner while provi...
Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
YouTube Video
Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
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New YouTube videos detected.

  • The Study of Stem Cells
    This video includes an overview of embryonic stem cells, their differentiation along lineage-specific pathways, and the epigenetic regulation and marks found in early embryonic development.
Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
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  • The Study of Akt
    This video provides in-depth information on upstream and downstream signaling mechanisms stemming from Akt and includes clinical ramifications of aberrant Akt signaling in causing disease (includes 3 sections)
Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
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New YouTube videos detected.

  • The Story of an Antibody
    Scientists at Cell Signaling Technology® (CST) follow stringent validation processes, using a combination of several approaches and applications, to provide you with the highly specific and thoroughly tested antibodies. This ensures credible and reproducible results with the least expenditure of your valuable time, samples, and reagents.
Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
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  • Jeffrey Settleman, Ph.D., The Many Flavors of Resistance To Anti-Cancer Drugs
    Jeffrey Settleman, Ph.D., the Senior Director of Discovery Oncology at Genentech, discussed his work investigating non-genetic/nonmutational drug-resistance to cancer therapeutics. "Understanding Signaling Pathways in Cancer", a symposium presented by the Koch Institute in partnership with Cell Signaling Technology, brought together speakers from leading cancer research organizations to present t...
Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
YouTube Video
Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
YouTube Video
Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
YouTube Video

New YouTube videos detected.

  • The Story of an Antibody, Whiteboard Edition
    CST has always believed that the only way to produce and validate our products is to do it in-house. That way, we can guarantee that they are rooted in sound science, supported by the most rigorous testing and customer service, and that our antibodies will be specific and reproducible tools available to research scientists. To learn more about the antibody validation process at Cell Signaling Tech...
Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
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  • The Future Is Electric: Cash Bonus for Electric Vehicles. Charge up at Work!
    In the U.S., sales of electric cars (EVs) are rising significantly, led by states that have signed a compact to bring over 3 million EVs to market by 2025. But in 2016, EVs were still just 1 percent of the new car market. We are lagging behind. Norway was at 24 percent of new cars, making it the leader by that measure.
Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
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  • Postcards from AACR
    Cancer research is near and dear to our hearts, but so is having a good time. AACR is an annual opportunity to get out of the office and get after both.
Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
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  • Successful Immunofluorescence: Antibody Dilution and Incubation Conditions
    Part four of a series on immunofluorescence techniques. Check out previous posts on Validation, Experimental Controls, and Fixation/Permabilization.  After your samples have been prepared, it's time to incubate them with a well-validated antibody, the workhorse of immunofluorescence. If you are a seasoned pro at IF experiments, you are probably used to checking the antibody datashe...
Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
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New blog articles detected.

  • In-depth characterization of immune checkpoints in the tumor microenvironment
    Characterize Immune Checkpoint Proteins and T Cell Exhaustion Using Multiplex IHC Advances in immuno-oncology have successfully led to novel cancer therapeutics with favorable patient responses that are more durable than conventional cytotoxic chemotherapy (1). However, not all patients respond to immunotherapy; therefore investigators are trying to identify clin...

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