Cell Signaling Technology, Inc. (CST) is a privately held company that develops and produces antibodies, ELISA kits, ChIP kits, proteomic kits, and other related regents used to study the cell signaling pathways that impact human health. CST maintains an in-house research program, particularly in the area of cancer research, and has published scientific papers in many peer-reviewed journals.

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Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
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  • Have you ever sat frozen at the keyboard, facing the due date for your abstract and asking yourself how you can condense all of this information into 200 words or less? If this scenario resonates with you, rest assured you are not alone. There is a learning curve for writing an effective abstract, and thankfully there are also some tips that will help you get started and finish strong.

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  •  You are all amped up to run a western blot to identify “your favorite protein.” The lysates have been run and proteins separated by SDS-PAGE. Now it’s time to transfer proteins from the gel to the membrane, and you’re sitting wondering….wet or semi-dry?? Or maybe you are better prepared than I was as a graduate student and you already know your next step, in which case you are aware of the pro...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • In Mr. D’s sophomore English class, almost no subject was taboo or off limits. Even with our class projects, he encouraged us to pursue topics that truly interested us, and sometimes that meant having to educate Mr. D about something entirely new to him. But if your presentation included stunning visuals, you had to be prepared to paint a word picture. Macular degeneration rendered his otherwis...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • The last few years have witnessed several breakthroughs in the immuno-oncology space. Treatments that harness the body’s immune system to fight cancer have transitioned from speculation to offering endless possibilities for drug discovery. Of these treatments, therapeutic monoclonal antibodies are positioned at the forefront of the immunotherapy revolution, and the FDA has approved several of t...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • Advances in mass spectrometry instrumentation and sample handling methods have propelled proteomics and extended its utility for both basic biology and early drug development. Changes in protein abundance and post-translational modification state often reflect the activity of a novel therapeutic agent as well as the sensitivity/resistance of a biological system to treatment.

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • It's Pi Day! 3.14! π! We've celebrated before, but this year we wanted to do something bigger. Don't get me wrong, we love baking and eating delicious pies, but have we waxed mathematical!? Well this year, CST's bravest of the brave ran our gauntlet of pi-related trivia! They didn't just eat pie, they earned it. Luckily, CST News anchor Jak Stat and the CST News team were live on the scene.

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • Let’s face it, we are an energy-intensive industry. From ultra low temperature freezers for storing products, to HVAC and lighting, plus lab equipment and fume hoods, it all adds up to a significant load. In 2017, CST’s two U.S. facilities used 7,677,140 kWh, which is the equivalent to the electrical consumption of 856 households! While creating that amount of energy on our own would require a ...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • Congratulations to our CEO and founder Dr. Michael J. Comb, whom CiteAb has selected for a lifetime achievement award. Dr. Comb likes fly-fishing in Alaska and rock climbing in Yosemite more than he likes the spotlight, but this award has given us the opportunity to acknowledge our fearless leader. CiteAb recognizes individuals from the research community for their dedication and contribution t...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • It’s Valentine’s Day. You can’t put out that bowl of candy hearts because…NO FOOD IN THE LAB!!! Okay, fair enough, but there has to be another way to send a message to someone special at the bench. Why not use antibodies to your advantage? The label of your vials might have all the messaging you need!

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • We as scientists learn from each success and failure. Sometimes it takes many failures to achieve success. And some discoveries are made with no fanfare, far from the spotlight. Other times, a good day’s work is even sweeter when you realize someone noticed!

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • So your experiments and data are funneling you down an inescapable path. You need to show direct gene regulation by your protein of interest. You think to yourself, “Oh, ChIP...”

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • The clinical validation of immune checkpoint inhibitors as immunotherapeutic agents for a variety of cancers has revolutionized the field of cancer therapy. While significant improvement in patient outcome has been observed with previously untreatable tumors, not all patients respond to these drugs (1). An advanced understanding of the immune regulatory context of the tumor microenvironment (TM...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • Type 2 diabetes is a growing epidemic, and is recognized as one of the most serious metabolic disease worldwide. A multifactorial disease, type 2 diabetes is a perfect example of metabolic miscommunication between different organs resulting in a pathological outcome. According to CDC in the United States, 29.1 million people in the United States have diabetes, and 8.1 million may be undiagnosed...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • The importance of antibodies as tools in scientific research studies cannot be understated, yet these reagents have increasingly come under fire for their lack of reproducibility. Part of the issue is that the antibody market is composed of hundreds of vendors and resellers with varying definitions for validation and consistency. Cell Signaling Technology (CST) believes that antibody suppliers ...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • With the arrival of the New Year, we all look back on 2017 and anticipate the coming year. CST scientists have been working hard to develop new antibodies and reagents to enable your next successful experiment in 2018! In Roman mythology, the New Year and the month of January are associated with Janus, the god of transitions and doorways (1). Janus is best known for having two faces: one looki...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • It's hard to believe that another year is almost over. We hope you're having a lovely holiday season with you and yours. We've been fairly busy closing another quarter. But it hasn't been all business. 'Tis the season for a little nonsense to fill us all with good cheer! We couldn't think of a better way than putting on some ugly sweaters and rocking the cafeteria.

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • Reuben Shaw, Ph.D Professor, Molecular and Cell Biology Laboratory, Deputy Director, Salk Cancer Center, The Salk Institute for Biological Studies AMPK, a highly conserved sensor of cellular energy status, is found in all eukaryotic cells and maintains metabolic homeostasis by reprogramming growth, metabolism, and autophagy in the face of cellular stresses.

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • In Nov 2017, over 30,000 neuroscientists gathered in Washington D.C. to talk all things brain. I’ve attended SfN for what is now on the order of decades. Having reluctantly accepted veteran status for the annual meeting, I thought this year’s SfN was an opportunity to consider where neuroscience has been, where it is, and where it’s going. The research objectives at SfN — to understand how mol...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  •   According to Bloomberg Business, the number of disposable gloves that are used in medical and life sciences amount to more than 100 billion each year1. But what does a number that large even mean? It has been suggested that if one stacked these gloves on top of each other they would be tall enough to reach to the moon and back 30 times. That’s a mega mountain of trash that’s slate...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  •   ABSTRACTThe cancer stem cell hypothesis postulates that a population of self-renewing tumor-initiating cells, termed Cancer Stem Cells (CSCs), may be responsible for driving tumor heterogeneity, metastasis, therapeutic resistance and/or tumor relapse. Tools to identify and characterize putative CSCs are therefore of significant value for the cancer research community. CD133 is a 5- ...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • PTMScan Proteomics: Identification and Quantification of Post-Translationally Modified Peptides Protein post-translational modifications (PTMs) regulate all aspects of cellular growth, development, and disease biology. Proteomic analysis of these PTMs has become central to gaining a better understanding of cellular signaling. Current proteomic methods and instrumentation allow for i...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • It's almost time for the 2017 Society for Neuroscience meeting. To get your neurons excited for the meeting, here's a journal club discussing a recent paper with interesting findings for Alzheimer's disease.  The pathological hallmark of Alzheimer’s disease (AD) is the accumulation of amyloid β (Aβ) plaques and neurofibrillary tangles. Despite decades of research, the direct (and indi...

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