Cell Signaling Technology, Inc. (CST) is a privately held company that develops and produces antibodies, ELISA kits, ChIP kits, proteomic kits, and other related regents used to study the cell signaling pathways that impact human health. CST maintains an in-house research program, particularly in the area of cancer research, and has published scientific papers in many peer-reviewed journals.

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Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
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  • Type 2 diabetes is a growing epidemic, and is recognized as one of the most serious metabolic disease worldwide. A multifactorial disease, type 2 diabetes is a perfect example of metabolic miscommunication between different organs resulting in a pathological outcome. According to CDC in the United States, 29.1 million people in the United States have diabetes, and 8.1 million may be undiagnosed...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • The importance of antibodies as tools in scientific research studies cannot be understated, yet these reagents have increasingly come under fire for their lack of reproducibility. Part of the issue is that the antibody market is composed of hundreds of vendors and resellers with varying definitions for validation and consistency. Cell Signaling Technology (CST) believes that antibody suppliers ...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • With the arrival of the New Year, we all look back on 2017 and anticipate the coming year. CST scientists have been working hard to develop new antibodies and reagents to enable your next successful experiment in 2018! In Roman mythology, the New Year and the month of January are associated with Janus, the god of transitions and doorways (1). Janus is best known for having two faces: one looki...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • It's hard to believe that another year is almost over. We hope you're having a lovely holiday season with you and yours. We've been fairly busy closing another quarter. But it hasn't been all business. 'Tis the season for a little nonsense to fill us all with good cheer! We couldn't think of a better way than putting on some ugly sweaters and rocking the cafeteria.

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • Reuben Shaw, Ph.D Professor, Molecular and Cell Biology Laboratory, Deputy Director, Salk Cancer Center, The Salk Institute for Biological Studies AMPK, a highly conserved sensor of cellular energy status, is found in all eukaryotic cells and maintains metabolic homeostasis by reprogramming growth, metabolism, and autophagy in the face of cellular stresses.

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • In Nov 2017, over 30,000 neuroscientists gathered in Washington D.C. to talk all things brain. I’ve attended SfN for what is now on the order of decades. Having reluctantly accepted veteran status for the annual meeting, I thought this year’s SfN was an opportunity to consider where neuroscience has been, where it is, and where it’s going. The research objectives at SfN — to understand how mol...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  •   According to Bloomberg Business, the number of disposable gloves that are used in medical and life sciences amount to more than 100 billion each year1. But what does a number that large even mean? It has been suggested that if one stacked these gloves on top of each other they would be tall enough to reach to the moon and back 30 times. That’s a mega mountain of trash that’s slate...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  •   ABSTRACTThe cancer stem cell hypothesis postulates that a population of self-renewing tumor-initiating cells, termed Cancer Stem Cells (CSCs), may be responsible for driving tumor heterogeneity, metastasis, therapeutic resistance and/or tumor relapse. Tools to identify and characterize putative CSCs are therefore of significant value for the cancer research community. CD133 is a 5- ...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • PTMScan Proteomics: Identification and Quantification of Post-Translationally Modified Peptides Protein post-translational modifications (PTMs) regulate all aspects of cellular growth, development, and disease biology. Proteomic analysis of these PTMs has become central to gaining a better understanding of cellular signaling. Current proteomic methods and instrumentation allow for i...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • It's almost time for the 2017 Society for Neuroscience meeting. To get your neurons excited for the meeting, here's a journal club discussing a recent paper with interesting findings for Alzheimer's disease.  The pathological hallmark of Alzheimer’s disease (AD) is the accumulation of amyloid β (Aβ) plaques and neurofibrillary tangles. Despite decades of research, the direct (and indi...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • You’re gathering data from all your experiments and preparing to present to your advisor and thesis committee at your annual progress report. You have an interesting hypothesis, and you have a validated antibody that recognizes your target protein on a western blot (WB). The molecular weight of the band is correct, and the expression of the target protein changes just the way you predi...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • Cell Signaling Technology is proud to partner with the Koch Institute at MIT, Science, and Science Signaling to present the Targeting Cancer Pathways webinar series. These webinars bring together thought leaders from around the world to share current findings and further cancer research community collaboration.

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • As a company that believes in leaving our mark on science, but not on the earth, CST has made a commitment to use compostable cups and plates in our US cafeterias.

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • This two part webinar features Dr. Li Huei Tsai from the Picower Institute at MIT and Dr. Raphael Rozenfeld who is a development scientist here at CST. Dr. Tsai discusses how modeling systems can be combined with immunolabeling and imaging techniques to unlock the mystery of Alzheimer's Disease. Dr Rozenfeld describes the rigorous validation procedure our antibodies undergo before be...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  •   If the thought of self-cannibalization is not appealing to you, you may not want to read the next sentence . . . Your cells are literally eating themselves right now! In the 1960s, Christian de Duve named this process “autophagy” from the Greek auto (self) and phagein (to eat). He was later awarded the Nobel Prize for Physiology or Medicine for his contribution to the cell biology f...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • Journal Club: YAP-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer. In the spirit of keeping you abreast of new and interesting scientific discoveries, the writers at CST have embraced the idea of a virtual journal club, where we discuss recently published scientific literature.

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • A picture is worth a thousand words, or in the case of immunofluorescent imaging, a thousand proteins. The images used to illustrate a scientific experiment should convey as much information as the text itself. Here at CST, we pride ourselves in the quality of our antibodies and our rigorous validation process. When we approve our primary antibodies for IF, we like to showcase them usi...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  •   If you’ve ever transitioned your IHC experiments from a manual protocol to an automated platform, you may have found the conversion process to be a drag. It isn’t an easy thing to do. For that reason, we’re happy to announce our IHC Leadership in Automation initiative. This rigorous validation initiative expands on our already thorough measures, allowing researchers to not only us...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • The development and testing of new products at Cell Signaling Technology (CST) involves the work of many teams using different techniques and technologies. This presents a variety of opportunities for summer interns to gain first-hand experience on projects ranging from bioinformatics to cell culture and staining tissue samples. For most students, a CST internship offers their first ex...

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • Once a year, we slow the centrifuges, quit the cloning, and lose the lab coats, all in honor of relaxation. Our company party gives us a chance to talk about everything outside the lab. We grab a glass of wine or beer and salute the delicious lobsters that fought so bravely. We kick soccer balls and toss Frisbees. We compare notes on sand castle construction.

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • Cell Signaling Technology is proud to present the following On-Demand Webinar:  The Use of Highly Validated Antibodies and Optimized ChIP Assays to Analyze Epigenetic Marks and Mechanism in DIsease Sayura Aoyagi, Ph.D, CST Antibody Validation Scientist

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • Early exploration of unmapped biological signaling pathways were carried out using radiolabeled phospho-imaging. The development of phospho-specific antibodies to detect and quantify protein phosphorylation made life easier for researchers (less 32P waste to deal with), but the interpretation of data from these experiments comes with its own set of caveats. 

Cell Signaling Technology (CST)
Cell Signaling Technology (CST)
Blog Post
  • INTRODUCTION: We encourage you to explore the rich history of antibodies and to share our passion for research supporting the next wave of innovations in this field. Download or Request our 125 Years of Antibody Discovery and Development to learn great facts like: The Antigen-Antibody binding hypothesis was proposed in 1938 Hybritech was first company to produce antibodies comm...

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