Cytoskeleton, Inc
Cytoskeleton, Inc
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Cytoskeleton, Inc
Cytoskeleton, Inc
Blog Article

New blog articles detected.

  • Citation Spotlight: ARNO-Arf1 Pathway Regulates RhoA Activity to Control Podosome Formation
    Arf activation by wild-type ARNO GEF in MDCK cells.  ARNO proteins localized with a 9e10 anti-myc primary antibody and CY2-conjugated secondary antibody (green).  F-actin labeled with rhodamine-phalloidin (red).  Cells expressing wild-type ARNO protein have robust lamellipodia (arrows).  Scale bar = 50 microns. Image provided by Dr. Lorraine Santy, Penn State University. Recentl...
Cytoskeleton, Inc
Cytoskeleton, Inc
Blog Article

New blog articles detected.

Cytoskeleton, Inc
Cytoskeleton, Inc
Blog Article

New blog articles detected.

  • May Newsletter: Arf6 GEFs and Cancer Cell Invasion and Metastasis
    Click to view this newsletter. The small GTPase ADP-ribosylation factor 6 (Arf6) belongs to the Arf subfamily of Ras superfamily GTPases. Of the three classes of Arf GTPases, Arf6 is the only member of class III and uniquely localizes to the plasma membrane and endosomes, positioning it to regulate cellular processes dependent upon dynamic changes in the actin cytoskeleton, including e...
Cytoskeleton, Inc
Cytoskeleton, Inc
Blog Article

New blog articles detected.

Cytoskeleton, Inc
Cytoskeleton, Inc
Blog Article

New blog articles detected.

  • April Newsletter: Post-translational Regulation of Phosphatase and Tensin Homolog (PTEN)
    Click to view this newsletter.  The phosphatidylinositol (3,4,5)-trisphosphate phosphatase and tensin homolog (PTEN) is a tumor supressor protein discovered 20 years ago by two independent laboratories1. PTEN is also known to regulate diverse cellular functions such as adhesion, migration, proliferation, growth, and survival. PTEN is composed of five domains: an N-terminal phosphatidyli...
Cytoskeleton, Inc
Cytoskeleton, Inc
Blog Article

New blog articles detected.

Cytoskeleton, Inc
Cytoskeleton, Inc
Blog Article

New blog articles detected.

Cytoskeleton, Inc
Cytoskeleton, Inc
Blog Article

New blog articles detected.

  • Citation Spotlight: Selective G12D K-Ras Inhibitors Discovered via Phage Display Technology
    GDP-K-Ras complexed to a phenol moiety (small arrow head; PDB code 4EPT; 2-hydroxyphenyl)(pyrrolidin-1-yl)methanethione) as described in Sun Q. et al. 2012. Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. Angew Chem. Int. Ed. Engl. 51, 6140–6143. Recently, Sakamoto et al. discovered novel peptide inhibitors of the G12D mutant K-Ras GTPase. Of ...
Cytoskeleton, Inc
Cytoskeleton, Inc
Blog Article

New blog articles detected.

  • February Newsletter: Actin-binding proteins and F-actin in dendrite cell migration
    Click to view this newsletter.  Dendritic cells (DCs) are antigen-presenting cells of the mammalian immune system that exist in either an immature, unactivated state or a mature, activated state. Immature DCs (iDCs) patrol peripheral tissues for foreign and/or pathogenic antigens (i.e., antigen sampling), localizing to sites of inflammation. Once there, iDCs find and internalize antigen...
Cytoskeleton, Inc
Cytoskeleton, Inc
Blog Article

New blog articles detected.

  • Citation Spotlight: Characterization of Novel 3D In Vitro Model of Cancer Cell Invasion
    Composition and architecture of extracellular matrix (ECM). Basement membrane is a type of ECM composed of laminin and collagen IV fibers embedded within a collagen I-enriched ECM. FNR01 image overlay with phase contrast background. Fluorescent fibronectin (Cat. # FNR01) treated MCF10A cells (image kindly provided by A. Varadara and M. Karthykenyan, Univ. S.Carolina, Columbia, S...
Cytoskeleton, Inc
Cytoskeleton, Inc
Blog Article

New blog articles detected.

  • New 2017 Cytoskeleton Minicatalog
    Click Here to Download New Products, New Discoveries! Signal Seeker Kits New SUMO Kits and More! GOBlot™ Western Blot Processor New Colors Available! Spirochrome Live Cell Reagents New Far-Red Probes!   Legend: Rac1 GTPase cycle regulation by phosphorylation New SUMO Signal Seeker™ Kit and More! The functional component of the SUMO 2/3 Enrichment Kit is an anti-SUMO-...
Cytoskeleton, Inc
Cytoskeleton, Inc
Blog Article

New blog articles detected.

  • Citation Spotlight: Rac1 GTPase activity: Role in Lung Cancer Proliferation, Migration, and Metastasis
    Swiss 3T3 cell stained with anti-vinculin (red), DAPI (blue nucleus) and F-actin is stained with Acti-stain™ 488 (green F-actin stress fibers, Cat.# PHDG1). Recently, Jeganathan et al. examined the role of intersectin-1s (ITSN-1s) in lung cancer proliferation, migration, and metastasis. These cellular processes require actin cytoskeleton re-arrangement typically regulated by...
  • Citation Spotlight: Rho-Family GTPase Activity: Key Components of Anti-Inflammatory and Neuroprotective Pathway
    Rac activation in Swiss 3T3 fibroblasts. F-actin is visualized with fluorescent green phalloidin staining (Cat.# PHDG1). DAPI is the blue nuclear stain. Phalloidin staining shows F-actin-rich lamellipodia. Cells were activated with Cat.# CN04. Recently, Rom et al. examined molecular pathways involved in leukocyte-mediated neuroinflammation given its causative role in neurona...
  • Custom Services Newsletter: Rho Family GTPases and Central Nervous System Injuries, Diseases, and Disorders
    Click to view this newsletter.  Effective treatments for central nervous system (CNS) injuries, diseases, and disorders remain a serious challenge for preclinical research scientists and clinicians This newsletter discusses some compounds that are in clinical trials or proteins/pathways that warrant consideration as therapeutic targets. Click to read more   Also included in this newslet...
  • November/December Newsletter: Small molecule inhibitors of GEF-mediated GTPase signaling
    Click to view this newsletter.  Ras and Rho-family GTPases regulate multiple cellular processes, including development, growth, motility, intracellular trafficking, gene expression, and the cell cycle1,2. Moreover, dysfunction of these GTPase are correlated with several human diseases (e.g., cancer, neurodegeneration, bacterial pathogenesis)3-5. Like all GTPases, Ras and Rho GTPase...
  • Citation Spotlight: Novel Tubulin Polymerization Inhibitor and Multidrug Resistance
    Crystal structure of tubulin-stathimine-colchicine complex. Recently, Zheng et al. identified and characterized a novel tubulin polymerization inhibitor discovered during anti-cancer compound screenings using the epithelial-mesenchymal transition (EMT)-mimetic assay. The lead compound was a nitrobenzoate molecule (2-morpholin-4-yl-5-nitro-benzoic acid 4-methylsulfanyl-benzyl ester), d...
  • Citation Spotlight: Rho GTPases and epidermal stem cell migration
    Rho activation in Swiss 3T3 fibroblasts. F-actin is visualized with fluorescent green phalloidin staining (Cat.# PHDG1). DAPI is the blue nuclear stain. Phalloidin staining shows F-actin-rich stress fibers. Cells were activated with Cat.# CN04. Recently, Zhan et al. investigated the molecular pathways underlying human epidermal stem cell (hESC) migration during wound repair to better ...
Cytoskeleton, Inc
Cytoskeleton, Inc
Blog Article

New blog articles detected.

  • September Newsletter: FtsZ Proteins: A Novel Anti-microbial Target
    Click to view this newsletter.  The tubulin homolog FtsZ (Filamenting temperature-sensitive mutant Z) protein is an essential prokaryotic cell divison protein. FtsZ is a GTPase that polymerizes in a nucleotide-dependent manner head-to-tail to form single-stranded filaments that assemble into a contractile ring called the Z-ring. This ring forms on the inside of the cytoplasmic membrane ...
  • Citation Spotlight: Rho GTPases and SNX9: Cancer Cell Invasion and Metastasis
    RhoGAP activity measured as GTP hydrolysis by RhoA protein. Each reaction contained reaction buffer + GTP with the addition of RhoA alone (RhoA), RhoGAP alone (GAP), or RhoA + RhoGAP (RhoA + GAP). Reactions were incubated at 37°C for 20 min. Phosphate generated by hydrolysis of GTP was measured by the addition of CytoPhos™ reagent and reading of absorbance at 650 nm. Recently, ...
Cytoskeleton, Inc
Cytoskeleton, Inc
Blog Article

New blog articles detected.

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