Thermo Fisher Scientific is an American multinational, biotechnology product development company, created in 2006 by the merger of Thermo Electron and Fisher Scientific. In April 2013, after a competitive bidding with Hoffmann-La Roche, Thermo Fisher acquired Life Technologies Corp for $13.6 billion in a deal that would rank the firm as one of the leading companies in the genetic testing and precision laboratory equipment markets.

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Thermo Fisher Scientific
Thermo Fisher Scientific
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  • As personalized cancer care evolves, the patient’s nucleic acid becomes ever so important to provide valuable information regarding their genetic makeup and disease state. Common sample types for these analyses include biopsies, which can be very limited in material making the downstream measurement of more than one analyte rather difficult. Obtaining another biopsy, using a different section or ...

Thermo Fisher Scientific
Thermo Fisher Scientific
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  • Study of genetic Information from cell-free (cf) DNA provide valuable opportunities in cancer research and potentially impact future oncology. As an example, liquid biopsy provide a non-invasive and cost effective solution for future compared to traditional biopsy tests. Here we report the application of research based Ion Torrent™ next-generation sequencing (NGS) Oncomine™ cfDNA assays and assoc...

Thermo Fisher Scientific
Thermo Fisher Scientific
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  • We developed Information Genetic Content (IGC), a comprehensive knowledgebase and discovery tool for human genes and genetic disorders research use. IGC comprises three components: the Disease-Association Database (DAD), the Gene Scoring Algorithm (GSA), and the Virtual Panel Library (VPL). The DAD module contains over 400,000 associations between over 17,000 genes and 15,000 Mendelian and comple...

Thermo Fisher Scientific
Thermo Fisher Scientific
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  • Blood screening to track tumor recurrence and resistance may improve treatment selection and monitoring. Virtually all tumors carry somatic DNA mutations, serving as biomarker in blood. Circulating cell-free DNA (cfDNA) is one source of tumor DNA in blood. Tumor DNA comes from different tumor clones, and its abundance in plasma can be very low at critical stages such as early recurrence or develo...

Thermo Fisher Scientific
Thermo Fisher Scientific
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  • We have developed an amplicon-based NGS approach for FFPE samples that can detect SNVs, small mutations and LRs simultaneously. We have implemented a comprehensive bioinformatics algorithm that detects LRs at high sensitivity, even in the absence of control sample(s). This significantly reduces the cost and labor for BRCA1/2 genetic analyses.

Thermo Fisher Scientific
Thermo Fisher Scientific
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  • At this time next generation sequencing (NGS) is hindered by slow and often manual workflow procedures. Decreasing overall workflow times is critical for the widespread adoption of targeted and whole genome sequencing (WGS) for many time-sensitive applications, in particular for infectious disease analysis. To this end, we describe improvements to the four main steps of the NGS workflow: i) libra...

Thermo Fisher Scientific
Thermo Fisher Scientific
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  • Detecting minor genetic variants has become essential to cancer and infectious disease management. Many have turned to next generation sequencing to fill this need given the common perception that the limit of detection (LOD) for Sanger sequencing is somewhere between 15% to 25%1,2,3. We have discovered a software algorithmic solution to reduce this detection limit to 5% and have demonstrated det...

Thermo Fisher Scientific
Thermo Fisher Scientific
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  • The effects of type and duration of tissue fixation were studied using three different lung (LCa) cancer research samples. Each tissue sample was fixed in five different fixatives, for three different time points in each fixative. Next generation sequencing (NGS), tissue morphology analysis (H+E), and antigenicity (IHC) were performed for each of the resulting samples. The analysis indicates that...

Thermo Fisher Scientific
Thermo Fisher Scientific
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Thermo Fisher Scientific
Thermo Fisher Scientific
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  • Learn more: http://www.thermofisher.com/us/en/home/industrial/forensics/human-identification/forensic-dna-analysis/dna-analysis/next-generation-sequencing-ngs-forensics.html Dr. Pedro Barrio, DNA expert with the National Institute of Toxicology and Forensic Sciences in Madrid, Spain is involved with the DNASEQEX project, and serves as a coordinator of the Mixture Commission of IFSG. Dr. Barrio ...

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